Key result
Formins, a family of fifteen proteins that regulate actin and microtubule dynamics, play multiple specialized roles in neural development and the developing brain.
This review highlights the specialized cellular activities of individual formin members in regulating actin and microtubule dynamics during neural development.
Dynamic control of the actin and microtubule cytoskeletons underlie nearly every critical process during neural development, and requires multiple dimensions of regulation. Formins are a family of fifteen proteins that functions as a major class of linear actin nucleators and regulates both actin and microtubule dynamics. The fact that several closely-related formins show complementary expression patterns during neural development and non-overlapping cytoskeletal functions indicates the need to identify the specialized cellular activities of individual formin members in different neural cell subtypes. In this review, we briefly introduce the known biochemical and regulatory functions of formins in the context of neural development, and summarize their cellular functions in the developing brain.
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Galbraith et al. (2018) conducted a review in Neural development. Formins was evaluated. Formins, a family of fifteen proteins that regulate actin and microtubule dynamics, play multiple specialized roles in neural development and the developing brain.
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