Key result
Acute Akt1 activation (2 weeks) altered 826 transcripts associated with reversible hypertrophy, whereas chronic activation (6 weeks) altered 1,611 transcripts linked to pathological heart failure.
Chronic Akt1 activation in the adult mouse heart induces distinct transcript expression profiles associated with the transition from compensatory hypertrophy to heart failure.
No takes yet. Share an insight, caveat, or question.
Distinguishes reversible from pathological remodeling transcripts in mice; leaves open whether Akt1 modulation can alter HF progression in humans.
Schiekofer et al. (2006) studied Cardiac hypertrophy and heart failure. Akt1 activation vs. Noninduced hearts was evaluated on Transcript expression profile changes. Acute Akt1 activation (2 weeks) altered 826 transcripts associated with reversible hypertrophy, whereas chronic activation (6 weeks) altered 1,611 transcripts linked to pathological heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: