Key result
Fractionation of bovine growth hormone yielded four components with distinct immunological, growth-promoting, and diabetogenic properties, indicating the hormone is a mixture of molecular forms.
Population
Bovine anterior pituitaries, tested in rat models and goats
Comparison
Four protein fractions of bovine growth hormone… vs Comparison among the four fractions (A, B, C, D)
Design
Preclinical
Authors
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GH preparations may contain multiple active forms with differing effects; leaves open the contribution of each to growth and metabolism in vivo.
Bovine growth hormone consists of a mixture of different molecular forms with distinct metabolic and immunological properties.
Hart et al. (1984) studied this question. Bovine growth hormone fractions (A-D) was evaluated on Immunological, growth-promoting, lipolytic, and diabetogenic activities. Fractionation of bovine growth hormone yielded four components with distinct immunological, growth-promoting, and diabetogenic properties, indicating the hormone is a mixture of molecular forms.
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