Population
In vitro rat epididymal fat, dwarf-mouse bioassay, and in vivo sheep (n=3)
Comparison
Recombinant-DNA-derived bovine growth hormone vs Pituitary bovine growth hormone (bGH)
Design
Preclinical
Authors
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Hypothesis-generating for intrinsic bGH diabetogenic effects; leaves open human translation and in vivo lipolytic mechanisms.
The lipolytic and diabetogenic activities of bovine growth hormone appear to be intrinsic properties of the molecule, though lipolytic activity may require in vivo modification.
Hart et al. (1984) studied this question.
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