Key result
bGH-M8 antagonizes GH-stimulated lipolysis while retaining full insulin-like antilipolytic activity in vitro.
Why the study?
Different domains of growth hormone may be responsible for its various biological activities, but the structural determinants for lipolytic versus antilipolytic effects were unclear.
The bGH-M8 analog demonstrates that different domains of growth hormone are responsible for its lipolytic versus antilipolytic activities.
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bGH-M8 separates GH lipolytic and antilipolytic domains in vitro; leaves open selective analog development for metabolic research.
Campbell et al. (1993) studied this question. bGH-M8 ([Leu117, Arg119, Asp122]-bGH) vs. bGH (bovine growth hormone) was evaluated on bGH-stimulated lipolysis and glucagon-induced lipolysis. The bovine growth hormone analog bGH-M8 acted as a competitive antagonist of GH-stimulated lipolysis (KB = 4.54 nM) while retaining full insulin-like antilipolytic activity in vitro.
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