Key result
Theoretical analysis suggests pituitary growth hormone may comprise distinct somatotrophic and diabetogenic entities.
Design
Review
Authors
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No immediate clinical implications for GH use; leaves open whether distinct somatotrophic and diabetogenic pituitary components exist.
This theoretical analysis proposes that the growth and diabetogenic effects of pituitary extracts may be driven by two distinct hormonal entities, aiming to stimulate further experimental validation.
Levine et al. (1964) conducted a review in Growth and diabetogenic effects of pituitary growth hormone. Pituitary growth hormone was evaluated. Theoretical analysis suggests the pituitary growth hormone fraction may comprise two distinct entities: a somatotrophic component for protein synthesis and a diabetogenic component for fat utilization.
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