Key result
Urinary N-terminal titin fragment concentrations were significantly increased in LGMDR1 patients compared to healthy controls.
Why the study?
The validity of urinary N-terminal titin fragment as a biomarker for limb-girdle muscular dystrophy LGMDR1-calpain 3 related required investigation.
Is urinary N-terminal titin fragment a valid biomarker for muscle damage in patients with limb-girdle muscular dystrophy LGMDR1?
Case-Control (n=24)
Is urinary N-terminal titin fragment a valid biomarker for muscle damage in patients with limb-girdle muscular dystrophy LGMDR1?
Urinary N-terminal titin fragment is a non-invasive biomarker of muscle damage in LGMDR1 that remains elevated even in wheelchair-bound patients.
Urinary titin may support noninvasive LGMDR1 monitoring; leaves open prospective validation before clinical use.
We aimed to investigate the validity of urinary N-terminal titin (TTN) fragment as a biomarker for limb-girdle muscular dystrophy LGMDR1-calpain 3 related. Thirteen LGMDR1 patients and eleven healthy controls were enrolled for the study. LGMDR1 patients had significantly increased urinary N-terminal titin fragment concentrations than age-matched controls. Even if urinary level of titin decreased with aging, it was still high in wheelchair bound patients. Thus, our findings indicate that urinary N-terminal titin fragment is a non-invasive measure of muscle damage in LGMDR1, which could be used in disease monitoring in clinical trials even in wheelchair-bound patients.
No takes yet. Share an insight, caveat, or question.
Valls et al. (2025) conducted a case-control in limb-girdle muscular dystrophy LGMDR1-calpain 3 related (n=24). LGMDR1 vs. healthy controls was evaluated on urinary N-terminal titin fragment concentrations. Urinary N-terminal titin fragment concentrations were significantly increased in LGMDR1 patients compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: