Key result
Urinary titin N-fragment is a promising biomarker for assessing muscle atrophy and intensive care unit-acquired weakness, with potential applications in post-intensive care syndrome management.
Why the study?
Urinary titin N-fragment has gained attention as a biomarker for muscle atrophy and ICU-acquired weakness, but its application in post-intensive care syndrome requires guidance.
Can urinary titin N-fragment serve as a useful biomarker for muscle atrophy and intensive care unit-acquired weakness in critically ill patients?
Can urinary titin N-fragment serve as a useful biomarker for muscle atrophy and intensive care unit-acquired weakness in critically ill patients?
Urinary titin N-fragment is a promising non-invasive biomarker for monitoring muscle atrophy and predicting post-intensive care syndrome to guide nutritional and rehabilitation management.
Answers are grounded in this paper and cite their sources.
Urinary titin N-fragment may support monitoring of muscle atrophy in critical illness; leaves open validation for predicting post-intensive care syndrome.
Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interplays the contraction of actin-containing thin filaments and myosin-containing thick filaments. The breakdown product of titin has been measurable in urine as urinary titin N-fragments. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.
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Nakanishi et al. (2020) conducted a review in Muscle atrophy, intensive care unit-acquired weakness, and post-intensive care syndrome. Urinary titin N-fragment was evaluated. Urinary titin N-fragment is a promising biomarker for assessing muscle atrophy and intensive care unit-acquired weakness, with potential applications in post-intensive care syndrome management.
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