Key result
Norovirus genogroup II was detected in 13.1% of young children hospitalized with acute gastroenteritis compared to ~2.5% in asymptomatic controls, with GII.3 and GII.4 being the most prevalent.
Observational (n=10,198)
Norovirus genogroup II is a significant cause of acute gastroenteritis in young children in Russia, with GII.3 and GII.4 being the predominant genotypes.
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Norovirus GII associated with pediatric hospitalizations in Russia; extends regional genotype data while leaving surveillance and vaccine needs open.
Noroviruses (NoVs) are an important cause of acute gastroenteritis worldwide. To monitor the molecular epidemiology of NoVs genogroup II (GII) in Novosibirsk, Russia, a total of 10,198 stool samples from young children hospitalized with acute gastroenteritis and two asymptomatic comparison groups were collected from 2003 to 2012. All samples were screened for the presence of NoV GII, rotavirus, and astrovirus by RT-PCR. The prevalence of NoV in gastroenteritis cases was 13.1%, varying from 7.1% to 21.3% in different seasons. Rotavirus and/or astrovirus were detectable in 25% of the NoV-positive samples. NoV was detected throughout the year with a seasonal increase during winter months. Based on sequence analysis of regions D and/or C within the VP1 gene, 892 identified NoV strains were divided into nine genotypes—GII.3 (51%), GII.4 (44%), GII.6 (2%), as well as GII.1, GII.2, GII.5, GII.7, GII.16, and GII.21 (totally, 3%). The prevalence of NoV in the comparison groups was considerably lower (∼2.5%); only GII.4 (n = 6), GII.21 (n = 2) and GII.1 (n = 1) genotypes were revealed. Based on phylogenetic analysis of the ORF1/ORF2 junction region sequences, GII.P21/GII.3 recombinant and GII.P4/GII.4 were prevalent genotypes (totally, 93%) and their ratio changed every season. The median age of children with NoV infection was 6.6 months (range, <1-35 months), but it was different depending on NoV genotype. Children infected with the NoV GII.3 were younger (median 6.2 months) than GII.4-positive patients (median 9.1 months). This is the first long-term systematic study of NoV molecular epidemiology in Russia.
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Жираковская et al. (2015) conducted an observational in acute gastroenteritis (n=10,198). Norovirus genogroup II (GII) vs. Asymptomatic comparison groups was evaluated on Prevalence of Norovirus. Norovirus genogroup II was detected in 13.1% of young children hospitalized with acute gastroenteritis compared to ~2.5% in asymptomatic controls, with GII.3 and GII.4 being the most prevalent.
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