A statistical model for the object and the complete image formation process in the cryo electron microscopy of viruses is presented. Using this model, maximum-likelihood reconstructions of the three-dimensional (3-D) structure of viruses are computed using the expectation maximization algorithm, and alternative experimental designs are evaluated based on Cramer-Rao bounds. Numerical examples of the reconstructions and experimental design evaluations are provided based on Cowpea mosaic virus.
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Doerschuk et al. (2000) studied this question.
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