Key result
In bovine aortic smooth muscle, calcium stimulated adenylate cyclase activity in the presence of calmodulin (half-maximal stimulation at 0.2 microM Ca2+).
Population
Microsomes isolated from bovine aortic smooth muscle
Comparison
Exogenous bovine testis calmodulin and varying… vs Absence of exogenous calmodulin
Design
Preclinical
Authors
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Suggests calmodulin-mediated calcium regulation of vascular adenylate cyclase; leaves open physiologic relevance in human cardiovascular disease.
Calcium at physiological concentrations can both stimulate and inhibit smooth muscle adenylate cyclase activity, with stimulation mediated by calmodulin.
Piascik et al. (1983) studied this question. Calcium and calmodulin vs. Absence of exogenous calmodulin was evaluated on Adenylate cyclase activity. In bovine aortic smooth muscle, calcium stimulated adenylate cyclase activity in the presence of calmodulin (half-maximal stimulation at 0.2 microM Ca2+).
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