Key result
Calmodulin activates adenylate cyclase in rabbit heart light sarcolemma in the presence of micromolar free Ca2+, an effect blocked by trifluoroperazine and troponin I.
Demonstrates that adenylate cyclase in the heart can be regulated by both calmodulin and guanine nucleotide-binding regulatory components.
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Hypothesis-generating for Ca2+-calmodulin regulation of cardiac adenylate cyclase; leaves open physiological relevance in intact systems.
Panchenko et al. (1984) studied this question. Calmodulin was evaluated on Adenylate cyclase activation. Calmodulin activates adenylate cyclase in rabbit heart light sarcolemma in the presence of micromolar free Ca2+, an effect blocked by trifluoroperazine and troponin I.
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