Key result
Advanced maternal age (≥35 years) was not associated with an increased risk of congenital heart disease compared to maternal age of 25 to 29 years (RR 0.99; 95% CI 0.89-1.09; p=0.97).
Why the study?
Does advanced maternal age increase the risk of congenital heart disease in offspring?
Population
4024 singleton cases of nonchromosomal congenital heart disease born between January 1, 1998, to December…
Comparison
Advanced maternal age (≥35 years at delivery) vs Maternal age 25 to 29 years at delivery
Design
Cohort
Authors
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Null CHD association with advanced maternal age warrants cautious reassurance; leaves open residual confounding in observational data.
Observational (n=4,024)
Does advanced maternal age increase the risk of congenital heart disease in offspring?
Relative Risk: 0.99 (95% CI 0.89–1.09)
p-value: p=0.97
Advanced maternal age is not associated with an increased risk of nonchromosomal congenital heart disease, supporting current UK practices that do not require specialist fetal echocardiography based solely on maternal age.
Best et al. (2016) conducted an observational in Congenital heart disease (n=4,024). Advanced maternal age (≥35 years) vs. Maternal age 25 to 29 years was evaluated on Congenital heart disease prevalence (RR 0.99, 95% CI 0.89-1.09, p=0.97). Advanced maternal age (≥35 years) was not associated with an increased risk of congenital heart disease compared to maternal age of 25 to 29 years (RR 0.99; 95% CI 0.89-1.09; p=0.97).
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