Key result
The prevalence of severe nonchromosomal congenital heart disease in Europe rose from 1990 to 2000 and subsequently declined (P<0.001 for trend).
p-value: p=<0.001
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Registry data from Europe show a significant decline in severe congenital heart disease prevalence since 2000, though the exact relationship with folic acid supplementation remains complex.
Dolk et al. (2010) conducted a letter in Severe congenital heart disease (n=3,614,371). Time period (1990-2006) was evaluated on Trend in prevalence of severe nonchromosomal congenital heart defects (p=<0.001). The prevalence of severe nonchromosomal congenital heart disease in Europe rose from 1990 to 2000 and subsequently declined (P<0.001 for trend).
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