Key result
In patients with non-ischemic dilated cardiomyopathy, elevated Galectin-3 (>13.8 ng/dL) significantly predicted mortality, ventricular tachyarrhythmias, or heart failure hospitalization (HR 2.66, p<0.001).
Why the study?
Although collagen turnover biomarkers are associated with myocardial fibrosis, their clinical utility remains limited, leading researchers to evaluate their link to CMR-detected replacement scarring and their combined prognostic value with LGE in NIDCM.
Do circulating collagen turnover biomarkers and late gadolinium enhancement predict outcomes in patients with non-ischemic dilated cardiomyopathy?
Population
194 patients with NIDCM
Comparison
Collagen turnover biomarkers (Gal3, PICP, PIIINP) and LGE presence on CMR
Design
Prospective cohort study
Follow-up
Median of 26 months
Authors
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Biomarkers correlate with LGE extent and outcomes in NIDCM; leaves open incremental value beyond CMR for prospective validation.
Cohort (n=194)
Do circulating collagen turnover biomarkers and late gadolinium enhancement predict outcomes in patients with non-ischemic dilated cardiomyopathy?
Hazard Ratio: 2.66
p-value: p=<0.001
Circulating collagen turnover biomarkers (particularly Gal3) and late gadolinium enhancement by CMR provide independent and incremental prognostic value for adverse outcomes in patients with non-ischemic dilated cardiomyopathy.
Revnic et al. (2022) conducted a cohort in Non-ischemic dilated cardiomyopathy (NIDCM) (n=194). Collagen turnover biomarkers (Gal3, PICP, PIIINP) and Late Gadolinium Enhancement (LGE) vs. Lower biomarker levels / LGE negative was evaluated on Composite of all-cause mortality, ventricular tachyarrhythmias, and heart failure hospitalization (HR 2.66, p=<0.001). In patients with non-ischemic dilated cardiomyopathy, elevated Galectin-3 (>13.8 ng/dL) significantly predicted mortality, ventricular tachyarrhythmias, or heart failure hospitalization (HR 2.66, p<0.001).
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