Key result
Administration of bevantolol after breakfast significantly delayed time to maximum concentration (1.8 vs 1.0 hours fasting) but did not affect Cmax or total drug absorption.
Why the study?
Does food ingestion affect the oral absorption and bioavailability of bevantolol in healthy volunteers?
RCT (n=12)
Open-label
crossover
Does food ingestion affect the oral absorption and bioavailability of bevantolol in healthy volunteers?
Food does not significantly affect the extent of bevantolol absorption, indicating the drug can be administered without regard to meals.
Answers are grounded in this paper and cite their sources.
Bevantolol may be taken without regard to meals; confirms food-independent bioavailability and supports flexible dosing in practice.
The bioavailability of bevantolol was compared in 12 healthy volunteers given single doses of the drug as the HCl salt after an overnight fast, or 15 minutes before or after a standardized breakfast in a nonblind, randomized crossover design. Bevantolol was rapidly absorbed in all three treatment groups, with maximum concentrations (Cmax) observed at 1.0, 0.9, and 1.8 hours for the fasting, before breakfast, and after breakfast groups, respectively. Time to Cmax was significantly longer than fasting only when bevantolol was given after breakfast. Food ingestion did not significantly affect Cmax, total of absorbed drug, or the drug elimination rate. Since food only slightly decreases the drug absorption rate and has no measurable effect on the extent of drug absorption, the relationship of bevantolol administration to meals is not expected to influence therapeutic efficacy.
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Toothaker et al. (1987) conducted an RCT in Healthy volunteers (n=12). Bevantolol given 15 minutes before or after a standardized breakfast vs. Bevantolol given after an overnight fast was evaluated on Time to maximum concentration (Cmax). Administration of bevantolol after breakfast significantly delayed time to maximum concentration (1.8 vs 1.0 hours fasting) but did not affect Cmax or total drug absorption.
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