Effect of Food, Food Constituents and Fluid Volume on the Bioavailability of Sotalol

P Kahela; Maarit Anttila; R Tikkanen; Hannu Sundquist

doi:10.1111/j.1600-0773.1979.tb02288.x

January 1, 1979Acta Pharmacologica et Toxicologica

Effect of Food, Food Constituents and Fluid Volume on the Bioavailability of Sotalol

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Why the study?

Does food, food constituents, or fluid volume affect the bioavailability of oral sotalol in healthy volunteers?

Key Points

To determine how food, specific dietary constituents, and fluid ingestion volume influence the rate and extent of oral sotalol bioavailability.
Administered a 160 mg oral dose of sotalol across six different experimental schedules in 5 healthy volunteers.
Obtained venous blood samples at 1, 2, 3, 4, 6, and 8 hours post-administration to quantify serum sotalol levels using fluorometric analysis.
Ingestion of large fluid volumes delayed the rate of sotalol absorption but did not alter the overall extent of systemic absorption.
Co-ingestion of food, particularly milk, significantly decreased sotalol bioavailability, with calcium binding identified as the primary factor inhibiting drug absorption.

Structured PICO

Does food, food constituents, or fluid volume affect the bioavailability of oral sotalol in healthy volunteers?

P

Population

5 healthy volunteers

I

Intervention

Oral sotalol 160 mg taken with food, specific food constituents (especially milk), or large volumes of fluid

C

Comparator

Different experimental schedules (six total, likely including fasting/baseline)

O

Outcome

Relative bioavailability of sotalol (serum concentrations measured at 1, 2, 3, 4, 6, and 8 hours post-dose)surrogate

Sotalol bioavailability is significantly reduced when taken with food, particularly milk, suggesting it should be taken on an empty stomach to ensure consistent absorption.

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Implication

May warrant empty-stomach dosing to optimize sotalol absorption; hypothesis-generating in healthy volunteers and needs confirmation in patients.

Abstract

The effect of food, some food constituents, and large volumes of fluid taken with the drug on the relative bioavailability of sotalol has been examined in five healthy volunteers. Each subject received an oral 160 mg dose in six different experimental schedules. Venous blood samples were drawn 1, 2, 3, 4, 6 and 8 hrs after the dosing, and sotalol concentrations in serum were determined fluorometrically. The results indicate that large volumes of fluid delay but do not affect the extent of sotalol absorption. Food, especially milk, decreases the bioavailability of the drug and an interaction with calcium seems to be the major reason for the reduced absorption.

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Cite This Study

Kahela et al. (1979) studied this question.

synapsesocial.com/papers/6a761f66212a5a9b7b708b93 https://doi.org/10.1111/j.1600-0773.1979.tb02288.x

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Effect of Food, Food Constituents and Fluid Volume on the Bioavailability of Sotalol

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effect of Food, Food Constituents and Fluid Volume on the Bioavailability of Sotalol

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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