Why the study?
Does sotalol alter heart rate and ECG intervals in healthy volunteers?
Population
n=7 healthy volunteers
Comparison
Sotalol 160, 240, and 320 mg/day for 10 days vs Placebo
Follow-up
14 days
Authors
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Should not yet change sotalol monitoring protocols; leaves open generalizability to patients with arrhythmias.
Does sotalol alter heart rate and ECG intervals in healthy volunteers?
Sotalol dose-dependently decreases heart rate and prolongs PR and QTc intervals in healthy volunteers, with some attenuation of the bradycardic effect over time at high doses.
Kantelip et al. (1986) studied this question.
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