Key result
A single 200-mg dose of sotalol significantly reduces resting and exercise-stimulated heart rate and plasma renin activity at 2 and 24 hours in healthy volunteers.
Why the study?
Does a single 200-mg oral dose of sotalol reduce resting and exercise-stimulated heart rate and plasma renin activity in healthy volunteers?
Population
Healthy volunteers
Design
Other
Follow-up
24 hours
Authors
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Demonstrates 24-hour beta-blockade in healthy volunteers; leaves open translation to once-daily use in patients.
Does a single 200-mg oral dose of sotalol reduce resting and exercise-stimulated heart rate and plasma renin activity in healthy volunteers?
A single 200-mg oral dose of sotalol provides 24-hour beta-adrenoceptor blockade, supporting its suitability for once-daily dosing in clinical practice.
Kiowski et al. (1979) studied this question. A single 200-mg dose of sotalol significantly reduces resting and exercise-stimulated heart rate and plasma renin activity at 2 and 24 hours in healthy volunteers.
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