Key result
Once-daily sotalol administration significantly reduced mean supine systolic blood pressure by 21% and diastolic blood pressure by 23% compared to pretherapy placebo values (P<0.001).
Why the study?
Does once-daily sotalol reduce blood pressure in patients with essential hypertension?
Population
n=15 patients with essential hypertension (including severe forms)
Comparison
Sotalol once daily for 12 weeks, with… vs Pretherapy placebo values
Design
Cohort, open study
Follow-up
12 weeks
Authors
Loading...
Should not yet change hypertension practice; hypothesis-generating for once-daily sotalol and requires randomized confirmation.
Does once-daily sotalol reduce blood pressure in patients with essential hypertension?
p-value: p=<0.001
Once-daily sotalol significantly reduces both systolic and diastolic blood pressure in patients with essential hypertension over 12 weeks.
RENATO PASQUEL (1979) studied Essential hypertension (n=15). Sotalol vs. Pretherapy placebo values (baseline) was evaluated on Supine systolic and diastolic blood pressure (p=<0.001). Once-daily sotalol administration significantly reduced mean supine systolic blood pressure by 21% and diastolic blood pressure by 23% compared to pretherapy placebo values (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: