What question did this study set out to answer?

To evaluate the longitudinal relationship between peripheral blood eosinophil levels and chronic asthma in childhood, and to determine factors influencing eosinophil patterns over time.

January 1, 2002Clinical & Experimental AllergyOpen Access

The association between persistent eosinophilia and asthma in childhood is independent of atopic status

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Authors

FKFazi̇let KarakoçPulmonary Associates SRST RemesKuopio University Hospital FMF.D. MartinezUniversity of Arizona

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Implication

Prospective cohort study demonstrates that persistent eosinophilia increases chronic asthma risk in children independent of atopy, indicating a potential distinct genetic mechanism.

Key Points

To evaluate the longitudinal relationship between peripheral blood eosinophil levels and chronic asthma in childhood, and to determine factors influencing eosinophil patterns over time.
Prospective cohort study of children (N=656 with ≥2 measurements) assessed for percent eosinophils per 300 white blood cells at 9 months, 6 years, and 11 years.
Categorized children into four eosinophil groups: persistently low (n=130), low (n=317), intermittently high (n=192), and persistently high (n=17).
Defined chronic asthma by physician diagnosis plus wheeze on ≥3 surveys between ages 2–13 years, and atopy by ≥1 positive skin prick test (wheal ≥3 mm) at age 6 or 11 years.
Chronic asthma prevalence increased linearly across eosinophil groups, ranging from 5.8% in persistently low to 37.5% in persistently high groups (trend chi2 P < 0.001), independent of atopic status.
Asthma risk increased by 70% per stepwise increase in longitudinal eosinophil category after adjusting for atopy and sex, which attenuated to 48% after adding parental asthma.
Parental asthma history was significantly associated with both chronic asthma (P < 0.001) and child longitudinal eosinophil status (P < 0.001).

Cite This Study

Karakoç et al. (2002) studied this question.

synapsesocial.com/papers/6a96ca7437dc33ab6afbc746 https://doi.org/10.1046/j.0022-0477.2001.01273.x

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Implication

Prospective cohort study demonstrates that persistent eosinophilia increases chronic asthma risk in children independent of atopy, indicating a potential distinct genetic mechanism.

The association between persistent eosinophilia and asthma in childhood is independent of atopic status

Discussion

Member takes

Implication

Key Points

Cite This Study

The association between persistent eosinophilia and asthma in childhood is independent of atopic status

Discussion

Member takes

Implication

Key Points

Cite This Study

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