Key result
Cefazolin achieved significantly higher plasma levels than cephradine during cardiopulmonary bypass (51.7 vs 26.6 mcg/ml; p<0.001) and most other phases of cardiac surgery.
Why the study?
Does cefazolin achieve higher antibiotic plasma levels compared to cephradine in adult patients undergoing cardiac surgery with cardiopulmonary bypass?
RCT (n=50)
Double-blind
randomized
Does cefazolin achieve higher antibiotic plasma levels compared to cephradine in adult patients undergoing cardiac surgery with cardiopulmonary bypass?
Absolute Event Rate: 51.7% vs 26.6%
p-value: p=<0.001
Cefazolin achieves significantly higher and more consistently therapeutic plasma levels than cephradine when used for prophylaxis during cardiac surgery with cardiopulmonary bypass.
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Supports cefazolin selection for prophylaxis in cardiac surgery with bypass; extends RCT pharmacokinetic data favoring its use.
Morán et al. (1986) conducted an RCT in Cardiac surgery with cardiopulmonary bypass (n=50). Cefazolin vs. Cephradine was evaluated on Antibiotic plasma levels during cardiopulmonary bypass (mcg/ml) (p=<0.001). Cefazolin achieved significantly higher plasma levels than cephradine during cardiopulmonary bypass (51.7 vs 26.6 mcg/ml; p<0.001) and most other phases of cardiac surgery.
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