September 24, 2008Journal of Vascular Research
Platelet Adhesion and Aggregation without Endothelial Denudation or Exposure of Basal Lamina and/or Collagen
Key result
Platelet adhesion and aggregation can occur over structurally intact endothelium, challenging the assumption that endothelial denudation is required for these processes.
Design
Review
Authors
Discussion
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Member takes
Implication
Questions endothelial denudation as prerequisite for thrombosis; leaves open mechanisms in intact vessels.
PICO
P
Population
Platelet adhesion and aggregation
Platelet adhesion and aggregation can occur over structurally intact endothelium, suggesting that endothelial denudation may be a result rather than a cause of aggregation in some cases.
Cite This Study
William I. Rosenblum (2008) conducted a review in Platelet adhesion and aggregation. Platelet adhesion and aggregation can occur over structurally intact endothelium, challenging the assumption that endothelial denudation is required for these processes.