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September 1, 1988Journal of Cardiac Surgery

Prognostic Importance of Viability and A Study of A Second Set Allograft Valve: An Experimental Study

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Why the study?

Does the transplantation of second set aortic valve allografts result in accelerated rejection compared to first set allografts in inbred rats?

Population

Inbred rats with varying histocompatibility

Comparison

Transplantation of first and second set aortic… vs Nonviable allografts

Design

Preclinical

Follow-up

Up to 250 days

Authors

AYA. C. YankahWWW. U. WOTTGEWMW Müller-Ruchholtz

Discussion

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Overview

May support repeat valve allograft use without accelerated rejection; leaves open human translation from this animal model.

Structured PICO

Does the transplantation of second set aortic valve allografts result in accelerated rejection compared to first set allografts in inbred rats?

P
Population
Inbred rats with varying histocompatibility
I
Intervention
Transplantation of first and second set aortic valve allografts in heterotopic infrarenal aortic position
C
Comparator
Nonviable allografts
O
Outcome
Immunological and histological changes including donor-specific antibody deposition, endothelial loss, cellular infiltrates, and graft degenerationsurrogate

Cardiac valve allografts exhibit weak antigenicity, suggesting that their use for secondary valve replacement might be favorable if antigen incompatibility is minimized.

Cite This Study

Yankah et al. (1988) studied this question.

synapsesocial.com/papers/6a96cf7ca43071aed1f6b8echttps://doi.org/10.1111/j.1540-8191.1988.tb00247.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANTIGENICITY OF FRESH AND CRYOPRESERVED RAT VALVE ALLOGRAFTS1990 · 63 citations
  2. 2Heart valve dysfunction resulting from cellular rejection in a novel heterotopic transplantation rat model2000 · 7 citations
  3. 3Patient Outcome and Valve Performance Following a Second Aortic Valve Homograft Replacement1999 · 29 citations
  4. 4Evolution of allograft aortic valve replacement over 13 years: results of 275 procedures2002 · 58 citations
  5. 5Heart valve dysfunction resulting from cellular rejection in a novel heterotopic transplantation rat model2000 · 6 citations