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April 1, 1990Transplantation

Antigenicity of Fresh and Cryopreserved Rat Valve Allografts

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Why the study?

Does cryopreservation reduce the antigenicity of aortic valve allografts in a rat model compared to fresh allografts?

Population

Lewis strain recipient rats receiving aortic valve grafts from donor rats of varying histocompatibility

Comparison

Transplantation of fresh or cryopreserved aortic… vs Sham operation followed 3 weeks later by skin…

Design

Preclinical

Follow-up

Time to skin graft rejection measured after 3 weeks…

Authors

HKHazem El KhatibFLFlavian M. Lupinetti

Discussion

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Overview

Antigenicity of rat aortic valve allografts persists after cryopreservation; should not yet inform human valve allograft selection.

Structured PICO

Does cryopreservation reduce the antigenicity of aortic valve allografts in a rat model compared to fresh allografts?

P
Population
Lewis strain recipient rats receiving aortic valve grafts from donor rats of varying histocompatibility (Lewis, F344, LBN F1, or BN strains)
I
Intervention
Transplantation of fresh or cryopreserved aortic valve allografts into the abdominal aorta, followed 3 weeks later by a skin graft from a strain syngeneic to the valve donor
C
Comparator
Sham operation followed 3 weeks later by skin grafting
O
Outcome
Time to skin graft rejectionsurrogate

Aortic valve allografts in rats are antigenic and produce recipient sensitization, which is not diminished by cryopreservation.

Cite This Study

Khatib et al. (1990) studied this question.

synapsesocial.com/papers/6a7dfd2b4776ec6335187ea0https://doi.org/10.1097/00007890-199004000-00022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunogenicity, Antigenicity, and Endothelial Viability of Aortic Valves Preserved at 4°C in a Nutrient Medium1991 · 46 citations
  2. 2Effect of Immunological Differences on Rat Aortic Valve Allograft Calcification1992 · 40 citations
  3. 3Prognostic Importance of Viability and A Study of A Second Set Allograft Valve: An Experimental Study1988 · 36 citations
  4. 4Heart valve dysfunction resulting from cellular rejection in a novel heterotopic transplantation rat model2000 · 6 citations
  5. 5Heart valve dysfunction resulting from cellular rejection in a novel heterotopic transplantation rat model2000 · 7 citations