March 1, 1992Journal of Cardiac SurgeryOpen Access

Effect of Immunological Differences on Rat Aortic Valve Allograft Calcification

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Why the study?

Does the degree of immunological difference between donor and recipient affect the calcification of aortic valve allografts in adult Lewis rats?

Population

Adult Lewis rats receiving aortic valve allografts transplanted heterotopically into the abdominal aorta

Comparison

Allogeneic aortic valve allografts from donors… vs Syngeneic aortic valve allografts from Lewis…

Design

Preclinical

Follow-up

3-12 weeks

Authors

FLFlavian M. LupinettiUniversity of Iowa SCSandra CobbDuke University HKHans C. Kioschos

Discussion

Member takes

Overview

Supports immunological mismatch in rat valve calcification; leaves open human allograft relevance.

Structured PICO

Does the degree of immunological difference between donor and recipient affect the calcification of aortic valve allografts in adult Lewis rats?

Population

Adult Lewis rats receiving aortic valve allografts transplanted heterotopically into the abdominal aorta

Intervention

Allogeneic aortic valve allografts from donors with varying degrees of allogenicity (F344, LBN F1, and Brown Norway strains)

Comparator

Syngeneic aortic valve allografts from Lewis donors

Outcome

Calcium content of one leaflet evaluated by scanning electron microscopy and energy dispersion x-ray microanalysis at 3-12 weeks following transplantationsurrogate

Syngeneic aortic valve allografts calcify significantly less than allogeneic grafts, though the degree of allogenicity does not further influence the magnitude of calcification.

Cite This Study

Lupinetti et al. (1992) studied this question.

synapsesocial.com/papers/6a7dfd2b4776ec6335187e9c https://doi.org/10.1111/j.1540-8191.1992.tb00776.x

View Full Paper

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March 1, 1992Journal of Cardiac SurgeryOpen Access

Effect of Immunological Differences on Rat Aortic Valve Allograft Calcification

View Full Paper

Ask AI

Bookmark

Why the study?

Does the degree of immunological difference between donor and recipient affect the calcification of aortic valve allografts in adult Lewis rats?

Population

Adult Lewis rats receiving aortic valve allografts transplanted heterotopically into the abdominal aorta

Comparison

Allogeneic aortic valve allografts from donors… vs Syngeneic aortic valve allografts from Lewis…

Design

Preclinical

Follow-up

3-12 weeks

Authors

FLFlavian M. LupinettiUniversity of Iowa SCSandra CobbDuke University HKHans C. Kioschos

Discussion

Member takes

Overview

Supports immunological mismatch in rat valve calcification; leaves open human allograft relevance.

Structured PICO

Does the degree of immunological difference between donor and recipient affect the calcification of aortic valve allografts in adult Lewis rats?

Population

Adult Lewis rats receiving aortic valve allografts transplanted heterotopically into the abdominal aorta

Intervention

Allogeneic aortic valve allografts from donors with varying degrees of allogenicity (F344, LBN F1, and Brown Norway strains)

Comparator

Syngeneic aortic valve allografts from Lewis donors

Outcome

Calcium content of one leaflet evaluated by scanning electron microscopy and energy dispersion x-ray microanalysis at 3-12 weeks following transplantationsurrogate

Syngeneic aortic valve allografts calcify significantly less than allogeneic grafts, though the degree of allogenicity does not further influence the magnitude of calcification.

Cite This Study

Lupinetti et al. (1992) studied this question.

synapsesocial.com/papers/6a7dfd2b4776ec6335187e9c https://doi.org/10.1111/j.1540-8191.1992.tb00776.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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