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March 1, 1989Transplantation

Cardiac Transplantation in the Rat

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Why the study?

Do prolonged, mild rejection reactions cause pathological changes such as arteriosclerosis and fibrosis in long-term cardiac allografts in rats?

Population

Inbred rat strains with selected histocompatibility differences (MHC class I or minor non-MHC antigens)

Comparison

Heterotopic cardiac allografts exchanged between… vs Syngeneic controls or allografts with more…

Design

Preclinical

Follow-up

long-term

Authors

DCDonald V. CramerUniversity of Southern CaliforniaSQSHIQUANG QIANCedars-Sinai Medical CenterJHJ O HARNAHAUniversity of Pittsburgh

Discussion

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Implication

Chronic allograft vasculopathy may reflect subclinical rejection; leaves open relevance to human transplants and requires clinical validation.

Key Points

  • To evaluate the impact of prolonged, mild rejection reactions on the development of vascular and myocardial pathology in long-term cardiac allografts.
  • Exchanged heterotopic cardiac allografts between inbred rat strains with specific MHC class I or minor non-MHC histocompatibility disparities.
  • Evaluated pathological changes across strains displaying mild prolonged rejection, active acute rejection, and syngeneic controls.
  • Rat strain combinations with mild, prolonged rejection developed diffuse interstitial myocardial fibrosis, perivascular fibrosis, and intimal proliferation in graft arteries.
  • Pathological vascular lesions were infrequent in syngeneic controls and strains differing only across MHC class I antigens, and were less prominent during active acute rejection.

Structured PICO

Do prolonged, mild rejection reactions cause pathological changes such as arteriosclerosis and fibrosis in long-term cardiac allografts in rats?

P
Population
Inbred rat strains with selected histocompatibility differences (MHC class I or minor non-MHC antigens)
I
Intervention
Heterotopic cardiac allografts exchanged between rat strains resulting in prolonged, mild rejection reactions
C
Comparator
Syngeneic controls or allografts with more active rejection
O
Outcome
Pathological changes in long-term cardiac allografts (diffuse interstitial myocardial fibrosis, perivascular fibrosis, and intimal proliferation in arteries)surrogate

Pathological changes such as arteriosclerosis in long-term cardiac allografts may reflect low-level, persistent allograft reactions rather than factors associated with graft anoxia or immunotherapy.

Cite This Study

Cramer et al. (1989) studied this question.

synapsesocial.com/papers/6a8a93ac755d28965dfd7398https://doi.org/10.1097/00007890-198903000-00002

Topics

Heart transplantation
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PATHOGENESIS AND PREVENTION OF GRAFT ARTERIOSCLEROSIS IN AN EXPERIMENTAL HEART TRANSPLANT MODEL1981 · 140 citations
  2. 2THE GENETICS OF BONE MARROW TRANSPLANTATION IN THE RAT1985 · 11 citations