Why the study?
Does anti-thymocyte globulin treatment induce permanent survival with chronic rejection features in a rat heart transplantation model?
Does anti-thymocyte globulin treatment induce permanent survival with chronic rejection features in a rat heart transplantation model?
Long-term surviving rat heart allografts induced by ATG treatment exhibit features of chronic rejection, providing a useful model for further studies of this process.
Long-term ATG-treated rat heart allografts exhibit chronic rejection features; leaves open a preclinical model for studying chronic allograft vasculopathy.
In a rat heart transplantation model, permanent graft survival was achieved by anti-thymocyte globulin (ATG) treatment of Wistar Kyoto (WKy) recipients before grafting with PVG/c hearts. Nine hearts with palpable and electrocardiographic (ECG) function 8-20 months after transplantation were studied with histological and immunohistochemical methods. The dominating findings were fibrosis, intimal thickening, thrombosis of vessels, cellular infiltrates, and a high number of cells expressing class II antigens. These findings suggest that reactions compatible with a chronic rejection can be found in long-term surviving rat heart allografts. This rat model may thus be used in further studies of a chronic rejection process.
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Claesson et al. (1988) studied this question.
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