Key result
Hypoplastic left heart syndrome was associated with a higher rate of subjective reduction in exercise tolerance compared with non-HLHS single-ventricle patients (72% vs 45%).
Why the study?
Do patients with hypoplastic left heart syndrome have worse physical and neurodevelopmental outcomes compared to non-HLHS patients with single-ventricle circulation surviving beyond age 10?
Observational (n=102)
No
Do patients with hypoplastic left heart syndrome have worse physical and neurodevelopmental outcomes compared to non-HLHS patients with single-ventricle circulation surviving beyond age 10?
Absolute Event Rate: 72% vs 45%
Children with HLHS surviving beyond age 10 have worse physical, psychological, and educational outcomes compared to other single-ventricle patients.
HLHS survivors may report greater exercise limitation; hypothesis-generating for targeted functional and neurodevelopmental assessment in single-ventricle patients.
OBJECTIVE: To investigate longer-term physical and neurodevelopmental outcomes of patients with hypoplastic left heart syndrome (HLHS) compared with other patients with functionally single-ventricle circulation surviving beyond the age of 10 years. DESIGN: A retrospective, observational study from a UK tertiary centre for paediatric cardiology. RESULTS: 58 patients with HLHS and 44 non-HLHS patients with single-ventricle physiology were included. Subjective reduction in exercise tolerance was reported in 72% (95% CI 61% to 84%) of patients with HLHS and 45% (31% to 60%) non-HLHS patients. Compared with non-HLHS patients, educational concerns were reported more frequently in patients with HLHS, 41% (29% to 54%) vs 23% (10% to 35%), as was a diagnosis of a behaviour disorder (autism or attention deficit hyperactivity disorder) 12% (4% to 21%) vs 0%, and referral to other specialist services 67% (55% to 79%) vs 48% (33% to 63%). CONCLUSIONS: Within a group of young people with complex congenital heart disease, those with HLHS are likely to have worse physical, psychological and educational outcomes.
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Davidson et al. (2014) conducted an observational in Functionally single-ventricle circulation (n=102). Hypoplastic left heart syndrome (HLHS) vs. Non-HLHS single-ventricle physiology was evaluated on Subjective reduction in exercise tolerance. Hypoplastic left heart syndrome was associated with a higher rate of subjective reduction in exercise tolerance compared with non-HLHS single-ventricle patients (72% vs 45%).
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