Why the study?
Does the plasma concentration-time curve (AUC) of total cyclophosphamide correlate with cardiac toxicity and tumor response in women with metastatic breast carcinoma?
Population
19 women with metastatic breast carcinoma receiving autologous bone marrow transplantation (ABMT)
Design
Cohort
Authors
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Lower cyclophosphamide AUC was associated with reversible CHF and durable response; leaves open whether AUC-guided dosing can balance toxicity and efficacy in metastatic breast cancer.
Does the plasma concentration-time curve (AUC) of total cyclophosphamide correlate with cardiac toxicity and tumor response in women with metastatic breast carcinoma?
Lower AUC of total (inactive) cyclophosphamide correlates with increased active metabolites, leading to both greater tumor cytotoxicity and increased but reversible congestive heart failure.
Ayash et al. (1992) studied this question.
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