Key result
A single 16 Gy radiation dose decreased total gastrocnemius muscle protein by 35% and RNA content by 20% compared to controls, whereas a fractionated 4x4 Gy dose did not alter these parameters.
Why the study?
Does radiation dose affect skeletal muscle remodeling in mice?
Population
24 female C57BL/6 mice (8 weeks old)
Comparison
Hindlimb irradiation with either a single 16 Gy… vs Non-irradiated control (sham procedures)
Design
Preclinical, Mice were randomly assigned to treatment groups, Fiber-type…
Follow-up
2 weeks after initial radiation exposure
Authors
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Fractionated dosing may spare murine muscle protein better than single high-dose radiation; leaves open clinical translation to radiotherapy.
Does radiation dose affect skeletal muscle remodeling in mice?
Absolute Event Rate: 9.1% vs 13.9%
p-value: p=<0.05
Radiation dose differentially affects skeletal muscle remodeling in mice, with higher biological effective doses causing more severe morphological changes such as decreased protein content and increased extracellular matrix volume.
Hardee et al. (2014) studied Skeletal muscle remodeling (n=24). Radiation vs. Non-irradiated control was evaluated on Total gastrocnemius muscle protein content (mg/muscle) (p=<0.05). A single 16 Gy radiation dose decreased total gastrocnemius muscle protein by 35% and RNA content by 20% compared to controls, whereas a fractionated 4x4 Gy dose did not alter these parameters.
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