Key result
Voluntary wheel running following juvenile irradiation improved fast-twitch extensor digitorum longus muscle-specific force by 37% and slow-twitch soleus muscle-specific force by 18%.
Why the study?
Radiotherapy for childhood cancers causes adverse effects on muscle function, but the underlying mechanisms remain incompletely understood.
Does voluntary wheel running improve skeletal muscle function and reduce mitochondrial stress in juvenile mice following irradiation?
Population
Juvenile male mice with localized hindlimb irradiation
Comparison
Voluntary wheel running vs locked running wheels
Design
Preclinical animal study
Follow-up
1 month
Authors
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Exercise may enhance muscle force after juvenile irradiation in animals; hypothesis-generating for pediatric radiotherapy patients.
Does voluntary wheel running improve skeletal muscle function and reduce mitochondrial stress in juvenile mice following irradiation?
Endurance exercise mitigates radiation-induced skeletal muscle functional decline, aberrant Ca2+ handling, and mitochondrial stress in a juvenile mouse model.
O’Connor et al. (2022) studied Juvenile irradiation-induced skeletal muscle functional decline. Voluntary wheel running vs. Sedentary (locked wheels) was evaluated on Fast-twitch extensor digitorum longus (EDL) muscle-specific force. Voluntary wheel running following juvenile irradiation improved fast-twitch extensor digitorum longus muscle-specific force by 37% and slow-twitch soleus muscle-specific force by 18%.
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