Population
Rabbit aorta and commercially available preparation of Na+-K+-ATPase
Design
Preclinical
Authors
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Hyperglycemia may impair vascular Na+-K+-ATPase via superoxide in diabetes; leaves open clinical relevance pending human studies.
Hyperglycemia increases endothelial superoxide production, which impairs NO-mediated stimulation of vascular smooth muscle Na+-K+-ATPase activity.
Gupta et al. (2002) studied this question.
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