Key result
Cardiac arrest produced by suddenly raising extracellular potassium to physiological levels after potassium deficiency is caused by selective inhibition of pacemaker activity.
Cardiac arrest following sudden restoration of physiological potassium after depletion is driven by selective pacemaker inhibition, suggesting a potential mechanism for sudden death in situ.
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Alerts clinicians to risks during rapid potassium repletion after depletion; leaves open translation to human sudden-death mechanisms.
Surawicz et al. (1963) studied Cardiac arrest. Sudden increase of extracellular potassium to physiological concentration after potassium-deficient perfusion vs. Increase of external potassium above physiological concentration was evaluated on Mechanism of cardiac arrest (electrocardiograms and transmembrane potentials). Cardiac arrest produced by suddenly raising extracellular potassium to physiological levels after potassium deficiency is caused by selective inhibition of pacemaker activity.
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