Key result
Reducing the sodium concentration in the perfusate of sheep or calf right ventricular myocardium altered action potentials, suggesting the sodium hypothesis applies to cardiac ventricles.
Population
Sheep's or calf's myocardium (m. transversus cordis of the right ventricle)
Design
Preclinical
Authors
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Extends sodium hypothesis to ventricular myocardium in large-mammal models; leaves open human clinical relevance.
Demonstrates that the sodium hypothesis applies to the cardiac ventricle using a novel mammalian myocardium perfusion preparation.
J. Délèze (1959) studied this question. Reduced Na concentration in perfusate was evaluated on Action potential changes. Reducing the sodium concentration in the perfusate of sheep or calf right ventricular myocardium altered action potentials, suggesting the sodium hypothesis applies to cardiac ventricles.
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