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July 1, 1956Circulation Research

A Muscle Column Preparation from the Rat's Left Ventricle

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Key result

A muscle column preparation from the rat left ventricle offers economic and technical advantages over other isolated heart muscle preparations for in vitro studies.

Population

Rat heart left ventricle (trabeculae carneae of the posterior ventricular wall)

Comparison

In vitro muscle column preparation vs Other types of isolated heart muscle…

Design

Preclinical

Authors

WUWilliam C. UllrickBoston UniversityWWWilliam V. WhitehornMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

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Implication

May enable accessible rat cardiac muscle studies; leaves open validation and translation to other models or species.

Structured PICO

P
Population
Rat heart left ventricle (trabeculae carneae of the posterior ventricular wall)
I
Intervention
In vitro muscle column preparation
C
Comparator
Other types of isolated heart muscle preparations currently in use
O
Outcome
Excitability, extensibility, tension development, and oxygen consumptionsurrogate

Describes a novel, economically and technically advantageous in vitro muscle column preparation from the rat left ventricle for studying cardiac physiology.

Cite This Study

Ullrick et al. (1956) studied this question. Muscle column preparation from rat left ventricle vs. Other types of isolated heart muscle preparations was evaluated on Excitability, extensibility, tension development, and oxygen consumption. A muscle column preparation from the rat left ventricle offers economic and technical advantages over other isolated heart muscle preparations for in vitro studies.

synapsesocial.com/papers/6a9fe74f16360f1e481de885https://doi.org/10.1161/01.res.4.4.499
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