July 1, 1987Experimental Biology and Medicine

The Right Ventricular Working Heart Preparation

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Structured PICO

Population

Isolated working rat hearts perfused with Krebs-Henseleit bicarbonate buffer via a Langendorff column

Intervention

Administration of inotropic agents: verapamil (5 X 10(-8) M), calcium (2.8 mM final concentration), or ouabain (5 X 10(-5) M) in a modified right ventricular working heart preparation

Comparator

Baseline conditions (fixed preload of 0 cm H2O or initial work curve with 1.9 mM Ca2+)

Outcome

Right ventricular performance (RV systolic pressure, maximum rise and decrease in pressure development [+/- dP/dt], and cardiac output) and changes in inotropysurrogate

The modified isolated working rat heart preparation is a stable and reproducible model for studying right ventricular pump function and its response to inotropic agents.

Discussion

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Implication

Rat heart model reliably detects inotropic effects; extends preclinical RV tools but leaves clinical translation open.

Cite This Study

Werchan et al. (1987) studied this question.

synapsesocial.com/papers/6a746a37f1e99ff85ab1be7b https://doi.org/10.3181/00379727-185-42554

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The Right Ventricular Working Heart Preparation

Structured PICO

Discussion

Implication

Cite This Study

The Right Ventricular Working Heart Preparation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider