Key result
Metabolic syndrome contributes to atherogenic dyslipidemia, hyperglycemia, and prothrombotic and proinflammatory states, adversely impacting outcomes and disease progression in vascular patients.
Metabolic syndrome significantly impacts the outcomes of vascular interventions through complex biological mechanisms involving insulin resistance, inflammation, and prothrombotic states.
Metabolic syndrome identification may inform vascular patient management; leaves open optimal therapeutic strategies for future trials.
Metabolic syndrome is highly prevalent in vascular patients and has a significant impact on the outcomes of vascular interventions. It comprises of a set of metabolically driven risk factors, including truncal obesity, dyslipidemia, elevated blood pressure and elevated fasting blood glucose. Increased insulin resistance within the context of obesity and hypertension contributes to atherogenic dyslipidemia, hyperglycemia, and prothrombotic and proinflammatory states which lead to the adverse impact of metabolic syndrome on the response to injury and on atherosclerotic disease progression. This review focuses on the complex biology of metabolic syndrome and its relevance to management of vascular patients, including outcomes and implications for the coronary, cerebrovascular and lower-extremity vascular beds.
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Vykoukal et al. (2012) conducted a review in Metabolic syndrome in vascular patients. Metabolic syndrome was evaluated. Metabolic syndrome contributes to atherogenic dyslipidemia, hyperglycemia, and prothrombotic and proinflammatory states, adversely impacting outcomes and disease progression in vascular patients.
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