January 18, 2017Pediatric Critical Care Medicine
Electrographic Seizures in Children and Neonates Undergoing Extracorporeal Membrane Oxygenation
Key result
Electrographic seizures in neonates and children on ECMO were associated with significantly higher pre-discharge mortality compared to those without seizures (72% vs 30%; p=0.01).
Why the study?
What is the prevalence and what are the risk factors for electrographic seizures in neonates and children requiring ECMO support?
Population
112 neonates and children requiring extracorporeal membrane oxygenation support at a quaternary care…
Design
Cohort
Follow-up
Until discharge
Authors
Discussion
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Member takes
Implication
Seizures were associated with higher mortality in pediatric ECMO; leaves open whether routine EEG monitoring improves outcomes.
Study Design
Type
Observational (n=99)
Multicenter
No
Structured PICO
What is the prevalence and what are the risk factors for electrographic seizures in neonates and children requiring ECMO support?
P
Population
99 neonates and children requiring extracorporeal membrane oxygenation support who underwent electroencephalographic monitoring.
E
Exposure
Electroencephalographic (EEG) monitoring
O
Outcome
Prevalence and risk factors for electrographic seizuressurrogate
Main Result
Absolute Event Rate: 72% vs 30%
p-value: p=0.01
Electrographic seizures are common in pediatric ECMO patients, often subclinical, and associated with increased mortality, highlighting the potential value of routine EEG monitoring.
Cite This Study
Lin et al. (2017) conducted an observational in Neonates and children requiring extracorporeal membrane oxygenation support (n=99). Electrographic seizures vs. No electrographic seizures was evaluated on Death prior to discharge (p=0.01). Electrographic seizures in neonates and children on ECMO were associated with significantly higher pre-discharge mortality compared to those without seizures (72% vs 30%; p=0.01).