Key result
Mechanical circulatory support with VA-ECMO and an Impella pump successfully bridged a patient with refractory cardiogenic shock from severe bupropion toxicity to full cardiac recovery.
Why the study?
Managing bupropion toxicity is challenging because there is no effective antidote and treatment is largely supportive.
Does mechanical circulatory support improve survival in patients with refractory cardiogenic shock due to bupropion toxicity?
Case Report (n=1)
No
Does mechanical circulatory support improve survival in patients with refractory cardiogenic shock due to bupropion toxicity?
Early utilization of mechanical circulatory support (VA-ECMO and Impella) can serve as a successful bridge to recovery in patients with refractory cardiogenic shock secondary to bupropion toxicity.
May support MCS consideration in bupropion toxicity shock; leaves open survival benefit in refractory cases.
Bupropion is a norepinephrine-dopamine reuptake inhibitor that is commonly used as an antidepressant and for smoking cessation. Bupropion overdose can lead to serious side effects which include seizures, status epilepticus, and fatal arrhythmias. Managing bupropion toxicity is challenging as there is no effective antidote and treatment is largely supportive. In this article, we present a case of bupropion toxicity causing profound cardiogenic shock which was treated successfully with mechanical circulatory support.
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Vilayet et al. (2024) conducted a case report in Bupropion toxicity with refractory cardiogenic shock (n=1). Mechanical circulatory support (VA-ECMO and Impella) was evaluated on Cardiac recovery and survival. Mechanical circulatory support with VA-ECMO and an Impella pump successfully bridged a patient with refractory cardiogenic shock from severe bupropion toxicity to full cardiac recovery.
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