Key result
Bupropion overdose in a 15-year-old boy resulted in torsades de pointes and cardiac arrest, highlighting potential severe cardiac toxicity.
Case Report (n=1)
Bupropion overdose can cause severe cardiotoxicity, including torsades de pointes and cardiac arrest, despite its reputation for lacking cardiotoxicity.
Raises caution for arrhythmia monitoring in bupropion overdose; extends sparse pediatric reports but remains hypothesis-generating.
Bupropion is an antidepressant that is currently used in the treatment of depression, attention deficit-hyperactive disorder, and bipolar diseases; as well as an aid in smoking cessation. Although its neurotoxicity and propensity to cause seizures are well described in the literature, bupropion has been suggested to be a more desirable antidepressant when compared to the tricyclic antidepressants due to its lack of cardiotoxicity. To date, there are limited reports with regard to cardiac toxicity. The authors present a 15-year-old boy who developed torsades de pointes and cardiac arrest as a result of a bupropion overdose. Other reports of potential cardiac toxicity related to bupropion are reviewed.
No takes yet. Share an insight, caveat, or question.
Gursahani et al. (2002) conducted a case report in Bupropion overdose (n=1). Bupropion overdose was evaluated on Torsades de pointes and cardiac arrest. Bupropion overdose in a 15-year-old boy resulted in torsades de pointes and cardiac arrest, highlighting potential severe cardiac toxicity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: