Key result
Diseased muscles contained two distinct groups of muscle fibers, one similar to normal innervated muscle and another similar to denervated muscle but with abnormal neuromuscular transmission.
Population
Extensor digitorum longus nerve-muscle preparations excised from mice having hereditary 'motor end-plate…
Comparison
Intracellular recording, stimulation, and… vs Normal innervated and chronically denervated…
Design
Preclinical
Authors
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Suggests heterogeneous neuromuscular involvement in murine motor end-plate disease; leaves open translation to human disorders.
Motor end-plate disease in mice presents with two distinct populations of muscle fibers, one resembling normal muscle and another resembling denervated muscle with abnormal neuromuscular transmission.
Samuel Weinstein (1980) studied Hereditary 'motor end-plate disease'. Hereditary 'motor end-plate disease' vs. Normal innervated and chronically denervated nerve-muscle preparations was evaluated on Electrophysiological properties (resting potentials, cable properties, neuromuscular transmission, miniature end-plate potentials). Diseased muscles contained two distinct groups of muscle fibers, one similar to normal innervated muscle and another similar to denervated muscle but with abnormal neuromuscular transmission.
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