Why the study?
Does exchange transfusion alter plasma concentrations of atrial natriuretic peptide and hemodynamic parameters in premature infants?
Does exchange transfusion alter plasma concentrations of atrial natriuretic peptide and hemodynamic parameters in premature infants?
In premature infants, acute blood replacement during exchange transfusion stimulates ANP release, whereas blood removal does not significantly affect ANP levels.
Blood replacement may stimulate ANP release during exchange transfusion in preterms; case report leaves open effects of depletion and requires prospective validation.
Plasma concentrations of atrial natriuretic peptide (ANP) and hemodynamic parameters were investigated in five premature infants undergoing exchange transfusion. Baseline values of ANP were 51.7 +/- 21.2 fmol/ml. Volume depletion by withdrawal of 10 ml blood did not cause changes in systolic blood pressure (79.4 +/- 4.3 vs. 71.4 +/- 5.6 mmHg) and heart rate (115 +/- 5.2 vs. 115 +/- 2.4 b/min). ANP levels in plasma remained unaltered (53.4 +/- 24.9 fmol/ml). Replacement of 10 ml blood increased central venous pressure by 33% and ANP concentration in the plasma by nearly 30%, while heart rate and blood pressure remained unchanged. Our data indicate that the heart of the premature infant responded to acute blood replacement with increased ANP-release, while blood removal appeared not to influence hormone regulation.
No takes yet. Share an insight, caveat, or question.
Khoór et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: