January 1, 1993Hypertension in Pregnancy

The Effect of Pregnancy on Maternal Central Circulation and Atrial Natriuretic Peptide Concentrations During Acute Plasma Volume Expansion

Q: What are the key findings of this study?

Pregnancy is associated with an enhanced increase in cardiac output (24% vs. 13%; P<0.05) and decrease in systemic vascular resistance during acute volume expansion compared to the nonpregnant state.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Healthy pregnancy (n=14). Intervention: Pregnancy vs. Nonpregnant state (3 months postpartum). Primary outcome: Cardiac output increase during acute volume expansion (p=< 0.05).

Q: What does this research mean for the field?

Normal pregnancy is associated with an enhanced increase in cardiac output and enhanced systemic vasodilatation during acute plasma volume expansion compared to the nonpregnant state, without a significantly altered atrial natriuretic peptide response. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Pregnancy is linked to a ~24% cardiac output increase and lower SVR during acute volume expansion.

P<0.05
n=14

Why the study?

Does acute plasma volume expansion alter central hemodynamics and ANP concentrations differently in pregnant women compared to their nonpregnant state?

Population

14 healthy pregnant women

Comparison

Rapid infusion of 0.9% Ringer solution, 15 mL/kg… vs The same women evaluated 3 months postpartum…

Design

Cohort

Follow-up

3 months postpartum

Authors

HNHenry NisellKarolinska University Hospital KCKjell CarlströmUppsala University IEIngvar EkKarolinska University Hospital

Discussion

Member takes

Overview

Supports pregnancy-specific vasodilatory responses to volume expansion; leaves open effects on hypertensive pregnancy management.

Study Design

Type

Observational (n=14)

Structured PICO

Does acute plasma volume expansion alter central hemodynamics and ANP concentrations differently in pregnant women compared to their nonpregnant state?

Population

14 healthy women evaluated during the third trimester of pregnancy and 3 months postpartum.

Exposure

Rapid infusion of 0.9% Ringer solution, 15 mL/kg body weight in the third trimester

Comparator

The same women evaluated 3 months postpartum (nonpregnant state) receiving the same infusion

Outcome

Echocardiography- and Doppler-derived circulatory measures and atrial natriuretic peptide (ANP) concentration before and immediately after infusionsurrogate

Main Result

Absolute Event Rate: 24% vs 13%

p-value: p=< 0.05

Normal pregnancy is associated with enhanced systemic vasodilatation during acute volume expansion compared to the nonpregnant state, without a significant difference in ANP response.

Cite This Study

Nisell et al. (1993) conducted an observational in Healthy pregnancy (n=14). Pregnancy vs. Nonpregnant state (3 months postpartum) was evaluated on Cardiac output increase during acute volume expansion (p=< 0.05). Pregnancy is associated with an enhanced increase in cardiac output (24% vs. 13%; P<0.05) and decrease in systemic vascular resistance during acute volume expansion compared to the nonpregnant state.

synapsesocial.com/papers/6aa6f467cfedc3e56e00a12c https://doi.org/10.3109/10641959309042871

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January 1, 1993Hypertension in Pregnancy

The Effect of Pregnancy on Maternal Central Circulation and Atrial Natriuretic Peptide Concentrations During Acute Plasma Volume Expansion

View Full Paper

Ask AI

Bookmark

Key result

Pregnancy is linked to a ~24% cardiac output increase and lower SVR during acute volume expansion.

P<0.05
n=14

Why the study?

Does acute plasma volume expansion alter central hemodynamics and ANP concentrations differently in pregnant women compared to their nonpregnant state?

Population

14 healthy pregnant women

Comparison

Rapid infusion of 0.9% Ringer solution, 15 mL/kg… vs The same women evaluated 3 months postpartum…

Design

Cohort

Follow-up

3 months postpartum

Authors

HNHenry NisellKarolinska University Hospital KCKjell CarlströmUppsala University IEIngvar EkKarolinska University Hospital

Discussion

Member takes

Overview

Supports pregnancy-specific vasodilatory responses to volume expansion; leaves open effects on hypertensive pregnancy management.

Study Design

Type

Observational (n=14)

Structured PICO

Does acute plasma volume expansion alter central hemodynamics and ANP concentrations differently in pregnant women compared to their nonpregnant state?

Population

14 healthy women evaluated during the third trimester of pregnancy and 3 months postpartum.

Exposure

Rapid infusion of 0.9% Ringer solution, 15 mL/kg body weight in the third trimester

Comparator

The same women evaluated 3 months postpartum (nonpregnant state) receiving the same infusion

Outcome

Echocardiography- and Doppler-derived circulatory measures and atrial natriuretic peptide (ANP) concentration before and immediately after infusionsurrogate

Main Result

Absolute Event Rate: 24% vs 13%

p-value: p=< 0.05

Normal pregnancy is associated with enhanced systemic vasodilatation during acute volume expansion compared to the nonpregnant state, without a significant difference in ANP response.

Cite This Study

synapsesocial.com/papers/6aa6f467cfedc3e56e00a12c https://doi.org/10.3109/10641959309042871

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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