Why the study?
Does pregnancy alter the baseline regulation of atrial natriuretic peptide (ANP) or its response to intravascular volume expansion?
Population
Normal pregnant subjects studied longitudinally commencing before 16 weeks of gestation, and age-matched…
Comparison
Intravascular volume expansion with either… vs Age-matched non-pregnant women
Design
Cohort
Follow-up
Longitudinal across pregnancy
Authors
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These adaptations may guide peripartum volume strategies; leaves open ANP's role in preeclampsia and requires prospective validation.
Does pregnancy alter the baseline regulation of atrial natriuretic peptide (ANP) or its response to intravascular volume expansion?
During normal pregnancy, baseline plasma ANP remains normal despite increased plasma volume, but its response to acute volume expansion is enhanced in late pregnancy.
Löwe et al. (1992) studied this question.
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