Atrial Natriuretic Peptide (ANP) in Normal Pregnancy; A Longitudinal Study
Why the study?
How do plasma levels of atrial natriuretic peptide (ANP) change longitudinally during normal pregnancy?
Population
23 nulliparous women during normal pregnancy
Design
Cohort
Follow-up
6 weeks post partum
Authors
Discussion
Loading...
Member takes
Implication
ANP may mark mid-gestational volume adaptation; leaves open its role in hypertensive disorders of pregnancy.
Structured PICO
How do plasma levels of atrial natriuretic peptide (ANP) change longitudinally during normal pregnancy?
P
Population
23 nulliparous women during normal pregnancy
C
Comparator
Values 6 weeks post partum (self-controlled)
O
Outcome
Plasma levels of atrial natriuretic peptide (ANP)surrogate
ANP levels peak around the 20th gestational week and correlate inversely with systemic vascular resistance and systolic blood pressure, suggesting a new volume set-point during pregnancy.
Cite This Study
Steegers et al. (1990) studied this question.