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January 1, 1988Acta Obstetricia Et Gynecologica Scandinavica

Plasma Atrial Natriuretic Peptide (Anp) And Maternal Hemodynamic Changes During Normal Pregnancy

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Key result

During normal pregnancy, plasma irANP increased significantly from 23.2 pM/l at week 12 to 25.9 pM/l at week 36 (p<0.05), and fell to 20.5 pM/l 3 months post partum (p<0.01).

Population

12 women with normal pregnancy

Design

Cohort

Follow-up

Up to 3 months post partum

Authors

IMIan MilsomSahlgrenska University HospitalJHJan HednerSahlgrenska University HospitalTHThomas HednerGeneral / Preventive / Lipids

Discussion

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Implication

ANP rise may aid volume homeostasis in normal pregnancy; observational data leave open its role in gestational hypertension.

Key Points

  • This research aims to explore the relationship between plasma atrial natriuretic peptide levels and maternal hemodynamic changes during normal pregnancy.
  • Studied 12 women longitudinally at weeks 12, 24, and 36 of pregnancy, and 3-5 days and 3 months postpartum.
  • Performed serial measurements of maternal hemodynamics concurrently with blood sampling for ANP levels.
  • Analyzed changes in cardiac output, stroke volume, heart rate, and vascular resistance.
  • Cardiac output, stroke volume, and heart rate significantly increased during pregnancy (p<0.001), while total peripheral vascular resistance decreased (p<0.001).
  • Plasma irANP increased from 23.2 pM/l at week 12 to 25.9 pM/l at week 36 (p<0.05).
  • Postpartum irANP levels fell to 20.5 pM/l three months post delivery (p<0.01).

Study Design

Type

Observational (n=12)

Structured PICO

P
Population
12 women with normal pregnancy followed longitudinally at 12, 24, and 36 weeks of pregnancy, and up to 3 months post partum.
O
Outcome
Changes in peripheral venous plasma concentrations of immunoreactive atrial natriuretic peptide (irANP) and maternal hemodynamics (cardiac output, stroke volume, heart rate, total peripheral vascular resistance)surrogate

Main Result

Absolute Event Rate: 25.9% vs 23.2%

p-value: p=<0.05

Plasma ANP levels increase during normal pregnancy alongside changes in maternal central hemodynamics, likely contributing to circulatory and volume homeostasis.

Cite This Study

Milsom et al. (1988) conducted an observational in Normal pregnancy (n=12). Advancing pregnancy vs. Early pregnancy (week 12) and post partum was evaluated on Plasma immunoreactive atrial natriuretic peptide (irANP) concentration (p=<0.05). During normal pregnancy, plasma irANP increased significantly from 23.2 pM/l at week 12 to 25.9 pM/l at week 36 (p<0.05), and fell to 20.5 pM/l 3 months post partum (p<0.01).

synapsesocial.com/papers/6a33033758530ca2eee121ffhttps://doi.org/10.3109/00016349809004295
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Release and regulation of atrial natriuretic peptide (ANP)1987 · 85 citations
  2. 2Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.1985 · 325 citations