February 1, 1991BJOG An International Journal of Obstetrics & Gynaecology
Atrial natriuretic peptide and atrial size during normal pregnancy
Why the study?
How do plasma atrial natriuretic peptide levels and atrial size change during normal pregnancy?
Population
21 nulliparous women during normal pregnancy
Comparison
Serial measurement of plasma atrial natriuretic… vs Measurements at 6 weeks post partum
Design
Cohort
Follow-up
6 weeks post partum
Authors
Discussion
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Implication
ANP and atrial size changes appear dissociated in normal pregnancy; hypothesis-generating for volume regulation mechanisms and should not yet change practice.
Structured PICO
How do plasma atrial natriuretic peptide levels and atrial size change during normal pregnancy?
P
Population
21 nulliparous women during normal pregnancy
I
Intervention
Serial measurement of plasma atrial natriuretic peptide (ANP) and atrial size during pregnancy
C
Comparator
Measurements at 6 weeks post partum
O
Outcome
Plasma atrial natriuretic peptide (ANP) concentrations and atrial size (right and left atrial areas, left atrial diameter)surrogate
During normal pregnancy, ANP levels peak in mid-pregnancy and atrial size increases in the third trimester without a direct correlation, suggesting an altered mechanism of ANP secretion to sustain hypervolemia.
Cite This Study
Steegers et al. (1991) studied this question.