Why the study?
Is plasma concentration of atrial natriuretic peptide elevated in pregnant women with preeclampsia compared to normal pregnant and nonpregnant women?
Is plasma concentration of atrial natriuretic peptide elevated in pregnant women with preeclampsia compared to normal pregnant and nonpregnant women?
Plasma ANP levels are significantly elevated in women with preeclampsia compared to normal pregnant and nonpregnant women, suggesting a potential pathophysiological link.
Answers are grounded in this paper and cite their sources.
ANP elevation in preeclampsia is hypothesis-generating; leaves open its diagnostic or prognostic value pending prospective validation.
Plasma concentration of atrial natriuretic peptide (ANP) was determined in pregnant women with preeclampsia, in normal pregnant and in nonpregnant women by a specific radioimmunoassay. Results did not show important differences between nonpregnant controls and normal pregnant women, but a significant rise was seen in women with preeclampsia compared to nonpregnant controls. Marked interindividual variation was found in all three groups. The mechanism of ANP release may differ between those women with normal pregnancy and those with preeclampsia. It is unclear whether the increased level of ANP in preeclampsia is an effect or a cause of the disease.
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Mikkelsen et al. (2010) studied this question.
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