Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 13, 1987BMJOpen Access

Atrial natriuretic peptide concentrations in pre-eclampsia.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are plasma atrial natriuretic peptide concentrations altered in pre-eclampsia compared to normal pregnancy?

Population

62 women, including healthy pregnant women in the third trimester, young non-pregnant controls, patients…

Comparison

Pre-eclampsia (mild and severe) vs Healthy pregnant women and young non-pregnant…

Design

Case-control

Authors

JTJ. K. ThomsenUniversity of CopenhagenTST. StormSteno Diabetes CentersGTGorm ThamsborgUniversity of Copenhagen

Discussion

Loading...

Member takes

Implication

Elevated ANP in pre-eclampsia may reflect non-pressure mechanisms; hypothesis-generating and should not yet change practice.

Structured PICO

Are plasma atrial natriuretic peptide concentrations altered in pre-eclampsia compared to normal pregnancy?

P
Population
62 women, including healthy pregnant women in the third trimester (n=22), young non-pregnant controls (n=25), patients with mild pre-eclampsia (n=9), and patients with severe pre-eclampsia (n=6).
I
Intervention
Pre-eclampsia (mild and severe)
C
Comparator
Healthy pregnant women and young non-pregnant controls
O
Outcome
Plasma immunoreactive atrial natriuretic peptide concentrationsurrogate

Pre-eclampsia is associated with markedly elevated plasma atrial natriuretic peptide concentrations that correlate with disease severity, suggesting that factors other than atrial pressure govern its release in this condition.

Cite This Study

Thomsen et al. (1987) studied this question.

synapsesocial.com/papers/6a72f59a1a70e69bd7154e84https://doi.org/10.1136/bmj.294.6586.1508
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of atrial natriuretic factor in rat pregnancy1986 · 26 citations
  2. 2The plasma release of atrial natriuretic peptide in man1986 · 132 citations
  3. 3Atrial Natriuretic Peptide: A New Factor in Hormonal Control of Blood Pressure and Electrolyte Homeostasis1986 · 90 citations
  4. 4Plasma Volume Contraction: A Significant Factor in Both Pregnancy-Associated Hypertension (Pre Eclampsia) and Chronic Hypertension in Pregnancy1979 · 252 citations